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About Us
We are a Hong Kong-based startup who are unsatisfied with current tissue diagnostics.
We challenge ourselves to develop pragmatic new technologies to surpass existing diagnostics limits and improve patient outcomes.
Our Mission
We develop 3D tissue diagnostics to assess the breadths and depths of tissue samples from biopsies and surgeries. The data is quantitative and accurate, allowing us to find the best drug options for the patients.
In contrast, current tissue diagnostics is limited to 2D, a flat and limited view causing inaccurate quantification and missed features. >50% cancer therapy fails if there is no accurate test to guide treatment, which is worse than a coin flip.
Our Tech
Developing 3D diagnostics is not trivial, requiring precise control of protein and light movements across tissue samples without damage and the analysis of massive image datasets.
Our platform quantifies multiple protein biomarkers across millions of cells in intact 3D tissue, preserving spatial relationships. This is achieved through advanced chemical staining, tissue clearing, and imaging with custom laser microscopes.
Latest Milestone
To date, we can reliably analyze 5mm tissue blocks in 3D H&E staining within 24 hours. Immunostaining with 4 biomarkers per round can be achieved in a day per millimeter of tissue. Our platform is compatible with fixed and wax-embedded specimens, and the process requires no specialized equipment and preserves tissue at the molecular level.
Partner with us to advance cancer diagnosis and treatment.
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Products and Services
our work
Data Science
New age of biological research
Electrical Signals
Biological Evaluation
Nature-Centered Design
*Beratung für Data Science
our team
Our Scientists
Joel Yamaha, PHD
Board Director
Ingrid Vulk, PHD
Senior Executive
Jenna Olsen, MBA
Principal Scientist
Rachel Gray, PHD
DevOps Lead Engineer
Important Update to OmniStain Protocols
We recently replaced methanol with tBuOH to better preserve endogenous fluorescence. However, some users have reported tissue distortion in large samples—an issue we had not prev
Fast, uniform, deep 3D nuclear staining BEFORE antibody staining
*This is a simple, robust and fast method for achieving uniform 3D nuclear staining in large, centimeter-scale tissues, including human tissues. Perform all steps at room temperatu
How To Test Your Antibodies (II)
Things to note when screening antibodies Be sure to include the tissue region of interest known to express the antigen. For example, if the antibody targets cytokeratin and a human
How To Test Your Antibodies (I)
Omnistain is compatible with a wide range of antibodies (https://illumos.co/insihgt-compatible-antibody-list/). However, as some antibodies prefer to work in one condition rather t
Why Is 3D Pathology Not There Yet?
Most would agree: 3D is better than 2D when it comes to diagnostics. CT and MRI scans are far more informative than plain X-rays. So, why is routine pathology still stuck in 2D? Le
Careers
Strive for Impact, Not Impact Factor
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Collaborations
Build 3D Spatial Biology Together
Investors
Play The Long Game With Us
